Cytotoxic antineoplastic drugs are administered to treat many different types of cancer including breast, lung, bladder and liver cancer. Doxorubicin (DOX) is a chemotherapy agent (also called Adriamycin) which is given by injection or drip (infusion) through a fine tube inserted into the vein (e.g. cannula), through a fine plastic tube inserted into a vein near your collarbone (central line) or into a vein in the crook of your arm (PICC line). Mathematical modeling can be used to determine DOX drug concentration in in systemic plasma, aggregate body tissue, tumor plasma, tumor interstitial space, and tumor cells. Such mathematical models allow optimization of drug delivery systems to achieve a better therapeutic index.
In the section below I present a mathematical model according to (http://www.musc.edu/ablation/pubs/Gasselhuber,%20PLos%20One%202012.pdf) to predict systemic and tumor drug concentrations for DOX in mice.
The ordinary differential equation model was built and solved via Python.
Showing posts with label doxorubicin. Show all posts
Showing posts with label doxorubicin. Show all posts
Tuesday, October 8, 2013
Thursday, June 20, 2013
Drug Delivery Modeling (Two Compartment Model/Conventional chemotherapy)
Have you ever wondered how long a drug injected via bolus stays in your system? If you want to know, than one possibility is to use computational models to find out. For drugs that move from the blood into other tissues a two compartment model is usually needed to characterize the drug distribution in the body. The schematic sketch of a two compartment model can look like:
In the following example I use Python to solve the Ordinary Differential Equations (ODE) to calculate the concentrations of doxorubicin (chemotherapeutic agent) in the body plasma and body tissue compartment.


additional infos simulation model:
http://www.musc.edu/ablation/pubs/Gasselhuber,%20PLos%20One%202012.pdf
In the following example I use Python to solve the Ordinary Differential Equations (ODE) to calculate the concentrations of doxorubicin (chemotherapeutic agent) in the body plasma and body tissue compartment.
additional infos simulation model:
http://www.musc.edu/ablation/pubs/Gasselhuber,%20PLos%20One%202012.pdf
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