Thursday, June 20, 2013

Drug Delivery Modeling (Two Compartment Model/Conventional chemotherapy)

Have you ever wondered how long a drug injected via bolus stays in your system? If you want to know, than one possibility is to use computational models to find out. For drugs that move from the blood into other tissues a two compartment model is usually needed to characterize the drug distribution in the body. The schematic sketch of a two compartment model can look like:

 In the following example I use Python to solve the Ordinary Differential Equations (ODE) to calculate the concentrations of doxorubicin (chemotherapeutic agent) in the body plasma and body tissue compartment.

additional infos simulation model:,%20PLos%20One%202012.pdf


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