This is my poster for the MUSC HCC Retreat 2013.
Thursday, November 7, 2013
Monday, October 14, 2013
Python Spyder, clear workspace/shell command
Python Spyder is a great Tool similar to Matlab but still lacking commands for clearing variables form workspace. I've added following code to the Spyder startup file (C:/Python27/Lib/site-packages/spyderlib/scientific_startup.py) to generate clear commands for workspace and the shell:
Tuesday, October 8, 2013
Cancer treatment with Doxorubicin (a mathematical model)
Cytotoxic antineoplastic drugs are administered to treat many different types of cancer including breast, lung, bladder and liver cancer. Doxorubicin (DOX) is a chemotherapy agent (also called Adriamycin) which is given by injection or drip (infusion) through a fine tube inserted into the vein (e.g. cannula), through a fine plastic tube inserted into a vein near your collarbone (central line) or into a vein in the crook of your arm (PICC line). Mathematical modeling can be used to determine DOX drug concentration in in systemic plasma, aggregate body tissue, tumor plasma, tumor interstitial space, and tumor cells. Such mathematical models allow optimization of drug delivery systems to achieve a better therapeutic index.
In the section below I present a mathematical model according to (http://www.musc.edu/ablation/pubs/Gasselhuber,%20PLos%20One%202012.pdf) to predict systemic and tumor drug concentrations for DOX in mice.
The ordinary differential equation model was built and solved via Python.
In the section below I present a mathematical model according to (http://www.musc.edu/ablation/pubs/Gasselhuber,%20PLos%20One%202012.pdf) to predict systemic and tumor drug concentrations for DOX in mice.
The ordinary differential equation model was built and solved via Python.
Wednesday, September 18, 2013
Low-cost, small animal thermal ablation system
The goal of this project was to develop a cheap, simple and robust ablation system for creating small thermal lesions in animals. As soon as biological tissues are exposed to temperatures > 40 degree Celsius for several minutes (~>30) tissue necrosis occurs and introduces cell death. This technique is used in cancer therapy to kill cells and to destroy tumors.
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Schematic of small animal ablation example in a mouse brain to study brain cancer treatments. |
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Schematic connection sketch for the micro-controller and electronic board. |
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Graphic user interface for the Thermistor control |
Links:
Thermistor:
http://www.mouser.com/ProductDetail/Honeywell/112-102EAJ-B01/?qs=F1jq4PciTHu%252b30xNPtI64w%3D%3D&gclid=CJzDjPjl1bkCFdSd4Aod5VYA8A
Wednesday, July 31, 2013
Radiofrequency tumor ablation with COMSOL (tutorial)
Radiofrequency ablation modeled with COMSOL |
Tissue ablation is the destruction of diseased (pathologic) tissue with the aim to cure a disease. One way to achieve this is via thermal methods (i.e. thermal ablation), by either heating or cooling to temperatures lethal to cells (typically below -40 °C (-40 °F), or above 50 °C (122 °F)). A number of different physical principles can be employed for heating and cooling tissue, such as radiofrequency (RF) electric current, microwaves, laser, ultrasound, and cryogenic cooling. In our lab we perform research on ablation using heating by RF currents, or cryogenic freezing.
In this tutorial I am using COMSOL to simulate radiofrequency tumor ablation for 15 minutes. Following will be covered in the tutorial:
- Radiofrequency heating via single cool-tip electrode
- Automatic Voltage PI-control for constant heating temperature in tissue
- Arrhenius tissue damage model
- Bioheat equation / perfusion decrease due to tissue damage
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